In vitro, TGF-β is one of the most effective inhibitors of hematopoietic stem cell (HSC) proliferation. TGF-β has been proposed to be a fundamental regulator of HSC quiescence, sustaining a slow-cycling state of HSCs in vivo, due to their inherently quiescent state. In vitro neutralization of TGF-β was demonstrated to wake up early hematopoietic progenitor […]