Bioinformatic Exam 1. (a) Why and when should you prefer PSI–BLAST over blastp? (b) Why e–values differ in PSI–BLAST from first search to second iteration? (c) What does PSSM stand for? Which BLAST search program uses the PSSM? (d) In what situation one needs to verify two putative homologs using pairwise alignment and why? 2. […]
Explain why there might be a bacterial homolog and how would you handle the “gap penalty?”
Bioinformatics Homework Review Article;An Overview of Multiple Sequence Alignments and Cloud Computing in Bioinformatics BY Jurate Daugelaite,1 Aisling O’ Driscoll, 2 and Roy D. Sleator 1 1.Why the “once a gap, always a gap” rule? Is it an insertion or a deletion? Does it matter? 2.Why might there be a bacterial homolog? What about the […]