Neurons
Answer the following questions.
Name a signaling molecule that has been shown to induce a caudal neuronal phenotype in the neural tube (Sances et al., 2016 pg 2 and Figures 1 and 2). (1 point)
Name a signaling molecule that has been shown to induce the ventralization of neurons in the neural tube (Sances et al., 2016 pg 2 and Figures 1 and 2). (1 point)
Describe a method used by researchers to determine the degree of motor neuron maturations (Sances et al., 2016, pg 7). (2 points)
The formation of corticospinal motor neuron from sub-cerebral projection neurons requires the expression of which transcription factor (Sances et al., 2016, pg 10-11). (2 point)
A mutation in the Chromosome 9 Open Reading Frame 72 (C9Orf72) gene has been identified as the most common form of familial ALS. What have researchers learned by making a mutation of C9Orf72 in human PSC-derived motor neurons in culture (Sances et al., 2016, pg 14)? (4 points)
