ASSIGNMENT
Q5.4.2 What model of selection is going on in this scenario? How do you know? (i.e. How do the relative fitness values compare to one another)?
Q5.4.3 What phenotype is being favored? What benefits does that phenotype have over the alternative possible phenotypes?
Q5.4.4 Will this population go to fixation? If so, which allele will become fixed? At which generation did this population reach fixation? (identify the exact generation where the population reached fixation, do not estimate based on the scatterplot you created). What phenotype will all members of the population express after it reaches fixat
Q5.5. Cholera is a bacterial infection of the small intestine that can lead to death by dehydration. In humans, the CFTR gene can affect a person’s ability to resist excessive body fluid loss:
Genotype Phenotype CC Average resistance to fluid loss Cc High resistance to fluid loss cc High resistance to fluid loss; cystic fibrosis
After a natural disaster, 12000 people are transplanted to a slum an under-developed region, where there is a high risk of cholera due to poor sanitation. At the time of the population’s settlement, 10830 people are CC, 1140 people are Cc, and 30 are cc. Cc individuals show high resistance to fluid loss and all of them survive to adulthood. CC individuals show average resistance to fluid loss and 60% of them survive to adulthood. cc individuals are highly resistant to fluid loss, but also suffer from cystic fibrosis (a genetic disease that can lead to lung damage and respiratory failure). 55% of cc individuals survive to adulthood. All members of this population who survive to adulthood bear an average of 2.2 offspring each.
Q5.5.1 Make a scatter plot of p and q over 30 generations.
Q5.5.2 What model of selection is going on in this scenario? How do you know? (i.e. How do the relative fitness values compare to one another)?
Q5.5.3 What phenotype is being favored? What benefits does that phenotype have over the alternative possible phenotypes?
Q5.5.4 Will this population go to fixation? If so, which allele will become fixed? At which generation did this population reach fixation? (identify the exact generation where the population reached fixation, do not estimate based on the scatterplot you created). What phenotype will all members of the population express after it reaches fixat
