Describe the experimental methods used by Phillips et al. to obtain the data in Figure 2. Discuss the deterministic model used by Phillips et al. (supplemental Text1).

Diversity in Lac operon regulation among Escherichia coli isolates

Sources:
1.Phillips KN, Widmann S, Lai H-Y, Nguyen J, Ray JCJ, Balázsi G, Cooper TF. 2019. Diversity in lac operon regulation among diverse Escherichia coli isolates depends on the broader genetic background but is not explained by genetic relatedness. mBio10:e02232-19. https://doi.org/10.1128/mBio.02232-19.
2.Setty et al. Detailed map of a cis regulatory function. PNAS 2003.

Goal: Describe the concepts leading to the surface plots shown in Figure 2 and supplemental Fig S2.

Contents MUST include these points below:
1.Introduce the function of the Lac operon regulatory network

2.Describe the experimental methods used by Phillips et al. to obtain the data in Figure 2

3.Discuss the deterministic model used by Phillips et al. (supplemental Text1)

Describe the experimental methods used by Phillips et al. to obtain the data in Figure 2. Discuss the deterministic model used by Phillips et al. (supplemental Text1).