Bioinformatics Homework
Review Article;An Overview of Multiple Sequence Alignments and Cloud Computing in Bioinformatics BY Jurate Daugelaite,1 Aisling O’ Driscoll, 2 and Roy D. Sleator 1
1.Why the “once a gap, always a gap” rule? Is it an insertion or a deletion? Does it matter?
2.Why might there be a bacterial homolog? What about the gap? How would you handle the “gap penalty?”
3.Find out what you can about Clustal Omega.
4.For those more familiar with HMMs, try to explain what the arrows mean. Feel free to refer to the original paper on ProbCons.
Explain why there might be a bacterial homolog and how would you handle the “gap penalty?”
