Biology of Aging
Note: Strictly no copy pasting your answers.
1. Differentiate between the two “rates” of aging: intrinsic versus extrinsic.
2. Life Expectancy at birth is….
3. How does income affect life expectancy?
4. From the discussion of cellular aging, explain the stochastic nature of cellular aging.
5. Distinguish between development, maturity and senescence.
6. How Bio gerontologists Study Aging: The Use of Laboratory Organisms in Human Aging Research.
7. Describe at least two reasons WHY model systems must be used to study human aging?
8. State an advantage AND a disadvantage to each of the following model systems used for studying aging in humans.
Fungi:
Sponges:
Insects:
Mice and rats:
Nonhuman primates:
9. Briefly describe each of the following and comment on the validity of each prediction.
Body size relation to maximum life span:
Brain size relation to longevity:
Basal metabolic rate relation to maximum life span:
10. Give a working definition of a Biomarker. Give characteristics of a good Biomarker.
11. Give 3 examples of methods used to measure age (other than the passage of time) (see the text and https://www.researchgate.net/figure/Summary-of-putative-biomarkers-of-aging_tbl1_303777364
12. Which do you think is more expensive to conduct, a longitudinal or cross-sectional study? Explain and indicate which provides more data:
13. Fill in the blank: ______ studies compare the average or mean rate of change in a particular physiological system between two or more age groups.
14. True or false: Longitudinal studies are no better at predicting the rate of aging and establishing a biomarker for aging than are cross-sectional analyses. Explain your answer:
15. Why was the BLSA methodology considered to be groundbreaking? List a main finding in each of the following areas?
16. Define:
Cardiology:
