This proposed project aims to develop three-dimensional (3D) collagen-based scaffold models suitable for the study of theepithelial to mesenchymal (EMT) processin prostate cancer. In particular, the work will assess the EMT process, an important step in metastatic progression, whereepithelial cells acquire mesenchymal characteristics(2) andincreased cellular plasticity, motility, drug resistance, and cancer stem cell features (3, 4), on two different scaffolds which have been developed in the TERG group:collagen-hyaluronic acid (CHyA) and collagen-chondroitin sulfate (CCS).
Develop three-dimensional (3D) collagen-based scaffold models suitable for the study of theepithelial to mesenchymal (EMT) processin prostate cancer.
